DNA testing company 23andMe has announced that they have reached the significant milestone of 100,000 individuals tested. 23andMe customers test for one or both of two reasons. Some test to gain some insight to into how their personal genome may affect their health. At this time 23andMe is not testing all genes that may have health implications. However, it is a start in allowing individuals to have direct information about how the genes they have inherited may affect their future health.
This approach is controversial because many in the medical community believe they should be the gateway to all information about our own bodies. Bob Grant writing yesterday in TheScientist: Magazine of the Life Sciences stated:
"According to a 2008 survey conducted by the American Medical Association (AMA) and Medco Research Institute, even though 98 percent of physicians agreed that the genetic profiles of their patients may influence drug therapy, only 10 percent believed they were adequately informed about how to test their patients for biomarkers that may predict the safety and/or efficacy of a particular drug."
Therefore it is important, and sometimes critically so, that such testing remain available on a direct to consumer basis. As some of you know the FDA has made some recent moves to restrict such testing that is not requested by a physician.
DNA testing for health information is just one side of the 23andMe business model. The company also tests for genealogical information. Although information is provided on mitochondrial and Y-chromosome haplotypes, it does not provide detailed reports on those two areas of DNA as do other testing companies like Family Tree DNA (FTDNA). On the other hand FTDNA does not test for health information. 23andMe's genealogy product is called "Relative Finder" and it can be compared with FTDNA's "Family Finder" product. Both are based on testing autosomal DNA rather than that found in the Y-chromosome or mitochondria. Buzz coming out of last week's Jamboree in Burbank gives hope that there may soon be utilities publicly available to compare autosomal results of Family Finder with those of Relative Finder. Dr D was born in Missouri the "Show Me" state so he is carefully watching for developments.
Back to 23andMe's milestone. The latest issue of the company's newsletter the spittoon, makes the following claims:
100,611 users genotyped
76% have agreed to participate in research
59% take surveys
57% are male
47% are sharing with other users
12% have multiple ancestry
45 is the average age
100,409 posts in our community forums
60,000 pairs of relatives among users
Explanations of mitochondrial, Y-chromosome and autosomal DNA testing can be found in earlier posts to this blog by searching "DNA" in the box in the upper left corner of the screen. Such information makes up the bulk of Chapter 10 in my just released Crash Course in Genealogy.