Monday, August 27, 2012

Finding Family: My Search for Roots and the Secrets of My DNA



I just finished Richard Hill's new book "FINDING FAMILY: My Search for Roots and the Secrets of My DNA." 

Blaine Bettinger who blogs as "The Genetic Genealogist" Published an excellent review that I just read after I had read the book myself.  I agree with everything Blaine said -- including the small criticism about the difficulty at a few points of following all the bit players without a scorecard. In this regard I hope Richard will consider inserting brief diagrams (dare I say pedigree charts) of some of the families he encountered along his quest to find his biological parents.

Even though I heard Richard recount this story as recently as last November, the twist at the end of the book was a surprise that kept me reading far too late into the night until I had finished the heartwarming saga. The story is engaging and those involved with DNA testing and/or traditional genealogy can learn much from the process and missteps Richard encounter along the way. Birth parents and adoptees searching for each other can learn many techniques and receive inspiration. Read
and learn.

Friday, August 24, 2012

zlyoga's Experience with 23andMe: The Videos


My wife discovered a very interesting video on YouTube on genetic testing through 23andMe. Actually, it is a series of two videos. Don't let the youthful demeanor of zlyoga fool you. She knows what she is talking about. The first was done when she submitted her spit sample for testing. The second was done about a year later: 

   

These videos are a good overview of the genetic testing being done at 23andMe. You probably should watch her earlier (2009) video first. This second video (2010) is a little dated in terms of 23andMe's policies but the explanation of the DNA testing and interpreting process is very comprehensive and is still very good.

Of the major US companies that provide direct to consumer (DTC) testing of DNA for genealogical purposes, 23andMe is the only one which also markets testing of genes that have health implications. Many of you will remember that the original impetus for starting 23andMe was largely to help find a cure for Parkinson's. Although most of our genome probably contains health related information, so far we do not know the purpose of much of it. Fortunately our knowledge increases on an almost daily basis. 

The other major DTC genetic genealogy testing services---Family Tree DNA and Ancestry---chose to avoid health implications and concentrate of family tree building. They have done this in an attempt to avoid the scrutiny of the FDA and the wrath of the medical community. The FDA has made tentative attempts to claim that DTC genetic testing is a medical device over which they can claim jurisdiction. Large portions of the medical community still believe that DTC genetic testing is something to which they should control access in order to protect the public. Both attitudes, if accepted, would slow the progress toward personalized, genome based, medical treatment that is on the horizon and has the potential to revolutionize medical practice. If can help us predict which drugs and other treatments are likely to be successful with specific patients and thus eliminate many that would be ineffective and even counterproductive. Both patient care outcomes and medical costs can be positively effected if we treat our bodies in ways that our individual genes are ready to accept.

Thursday, August 23, 2012

72 Hour DNA Sale @ FTDNA


Family Tree DNA has just announced a three day sale aimed at individuals who have not yet tested. If you are interested in exploring cousins in any line of your pedigree chart, this would be a great opportunity to start. These test bundles both include the Family Finder autosomal test which is good at finding close cousins on any of your lines. It will return matches with some of your more distant cousins who have tested but not all of them. Your match rate becomes significantly and increasingly smaller with each generation beyond third cousin. 

Both men and women can take advantage of this sale. However, women can only take the Family Finder + mtDNA option as women do not have Y-chromosome DNA. The Y-DNA 12 and the mtDNA tests bundled with Family Finder for this sale are entry level tests. They will give a vague indication of deep ancestry but matches at this level will not be useful for identifying specific relatives in the database. On the other hand, they can definitely eliminate many potential relatives who belong to different ancient tribes than the person being tested. While the Family Finder test is as definitive as any autosomal test on the market, the two tests with which it is bundled for this sale should be considered as entry level only. Those taking advantage of the sale price for genealogical purposes, will probably want to expand the Y-chromosome or the mitochondrial portions at a later date--possibly at the next sale aimed at existing customers. 

Dear Family Tree DNA Project Administrator,
This is a courtesy e-mail to you about a promotion that we have announced to all our customers, and therefore you don't need to re-post it in your administrators' bulk e-mail system.
It seems that every time we run a super sale that a few people email us days later that they were traveling, sick or just hadn't looked at their emails in time, so for all of you who have wanted to entice a friend, neighbor or reluctant relative to get involved in Genetic Genealogy here's one more opportunity, but it will last for only 72 hours.
These are the only two options on sale, and they are geared specifically for newcomers. This sale will end on Saturday, August 25, at 11:59PM.
New Customers Only
Current Price
SALE PRICE
$339
$249
$339
$249
As with all promotions, orders need to be placed by the end of the sale and payment must be made by end of this sale. Learn More



Tuesday, August 21, 2012

Where Did My Genes Come From?


DNA can be mind numbingly precise; but there is so much more that we have yet to learn. One example of this is our attempts to determine our geographic and ethnic origins. The chart below gives the current such projections for Dr D:


If you can read the chart above, Ancestry projects that 71% of my DNA is compatible with origin in the British Isles and 25% appears to be of Eastern European origin--leaving 4% uncertain.  23andMe tells me that I am more than 99% European, less than 1% Asian and 0% African. Family Tree DNA (FTDNA) reports that 94.36% plus or minus 1.72% of my DNA is compatible with Western European origin; and 5.64% (again plus or minus 1.72%) is of Middle Eastern origin.

Hmm? I'm glad I got that all sorted out. What else did these lab reports tell me? 23andMe specified that the Asian component (less than 1%) is on Chromosome 1. FTDNA equates my Western European overwhelming majority as being compatible with Orcadian (Orkney Islands?) DNA. The remaining Middle East component is classified as "Palestinian, Adygei, Bedouin, Bedouin South, Druze, Iranian, Jewish, Mozabite." 

This all must have been confused by my 2.5% Neanderthal DNA which 23andMe found. As a point of reference, this put me at the 39th percentile of Northern Europeans who are said to average 2.6%. My wife and her sister scored at the 95 percentile with 3% Neanderthal DNA. I want a recount! It looks like I may get it with Gene 2.0 which claims to test Neanderthal as well as Denisovan DNA.

So what have I learned as a result of these analyses? I have learned to take these reports, at their current state of evolution, with a grain (or perhaps a shaker) of salt. They point in the right direction but the exact point of origin of my various deep ancestors are still a little murky. These predictions are based on autosomal DNA so it encompasses all my lines and not just the paternal > paternal... (Y-chromosome) and the maternal > maternal... (mitochondrial) lines. I hope more experience and more individuals testing will sharpen the focus of these emotionally fascinating tests. 

Thursday, August 16, 2012

Autosomal Testing of Multiple Family Members



We all know that autosomal DNA is inherited is rather random way. Although each parent contributes essentially half of a child’s DNA, it is hard to predict how much of that half comes from each grandparent. We are all still learning how best to understand the test results.  

Testing the autosomal DNA of multiple family members can have several advantages. One of the more obvious is that test results for a paternal or maternal relative can greatly reduce the part of your family tree you need to search when a match from an unplaced relative is made. Since I do not have the option of testing my parents I have used a paternal first cousin and a maternal first cousin – once removed as surrogates.  I made a small experiment to see how helpful the autosomes of my cousins might be. I also compared the test results of my son and daughter with those of my 57 projected “distant relatives” who were predicted to be my 3rd or 4th cousins by FTDNA. The table below shows my preliminary findings:

Family Finder "Distant Relatives" 
Predicted 3rd or 4th Cousins
"Distant Relatives"
Me
1st Cousin
(father’s side)
1st Cousin -- 1 removed
(mother’s side)
Daughter
Son
Total
56
38
47
43
47
My closest
"Distant" matches
No other match

My matches that also matched one of these close relatives
1-10
0
2
1
6
2
11-20
2
0
2
5
5
21-30
1
3
1
5
3
31-40
4
2
0
5
2
41-50
8
0
1
0
1
51-57
2
0
0
1
3
Total
17
7
5
22
16

As you see 7 of my 57 “distant relative” matches were shared by my paternal first cousin. Also 5 of my 57 matches were shared with my maternal first cousin – once removed. As I had expected none of these 12 matches overlap. So it appears that a match with one or the other of these two cousins should narrow my search for our common ancestry to one side of my family.

Other findings were not as predictable. Twenty-two of my “distant relatives” were shared with my daughter and 16 with my son. Of those 5 of their matches overlapped and they had 28 unique matches between them.

My children share one of their 5 common matches with each of my two cousins. In addition, each child independently shares one separate match with each of my cousins. Actually, my son shares two with my first cousin – once removed that are not shared with his sister.

Of my 57 matches the 14 strongest matches are shared with at least one offspring or cousin and 23 of the strongest 25 are so shared. Only 11 of the next 25 are so shared. Four of the weakest 7 matches are shared. It is possible that some of the 19 unshared (with close family members) actually would show up as “remote matches.” I may extend my little analysis to see if this is true. If I do I’ll add the results to the blog at that time.

Also of possible interest is to explore further the extent to which full siblings share matches with distant and remote relatives.  

Sunday, August 5, 2012

1940 US Census Completely Indexed @ Ancestry.com


All 132 million individuals enumerated in the 1940 US Census images are now indexed and searchable by name at Ancestry.com. Congratulations to Ancestry. This monumental feat was accomplished in half the time I had expected it to take. Even if you do not have a paid Ancestry subscription, you may search these records free of charge -- at least until the end of 2013. Enjoy and learn about your family.


In addition to the all-name index, Ancestry has greatly improved the our viewing experience. A few of these enhancements are described below:


1. The names on the sheet are "typed out" as the indexer deciphered them. (see above arrow)
2. Abbreviated headings for each column are anchored and do not scroll out of sight. (see to right of arrow) 

3. An index of key information content can be viewed at the bottom of the screen by clicking  on the "Index" tab at the bottom of the screen. This feature can be hidden if you prefer not to see it. (see to right of arrow)

At this writing the consortium headed by FamilySearch has completed the indexing for about two-thirds of the states and territories and is nearing completing of many of the remaining areas. This project promises to provide free access perpetually.